plum.science Lab News

DOCK8 in T cells promotes Th17 and Treg cell functionality to restrain mucosal mast cells and limit susceptibility to oral anaphylaxis

Wed, 20 May 2026 13:53:05 +0000

Interleukin-4-producing type 2 innate lymphoid cells in the lymph node promote proallergic Tfh13 cell differentiation

Wed, 20 May 2026 13:51:56 +0000

Online now: Interleukin-4-producing type 2 innate lymphoid cells in the lymph node promote proallergic Tfh13 cell differentiation

Vip+ vagal neurons control allergen-induced responses

Wed, 20 May 2026 13:51:04 +0000

Vip+ vagal neurons control allergen-induced responses

The Neuroimmune Circuitry of Peripheral Sensory Neuron Subtypes in Chronic Pain

Wed, 20 May 2026 13:50:26 +0000

Review @annualreviews.bsky.social
The Neuroimmune Circuitry of Peripheral Sensory Neuron Subtypes in Chronic Pain
www.annualreviews.org/content/jour...

Tuft cells promote reactivation of memory Th2 cells and are required for protective immunity to intestinal helminth re-infection

Wed, 20 May 2026 13:48:29 +0000

Online now: Tuft cells promote reactivation of memory Th2 cells and are required for protective immunity to intestinal helminth re-infection

Early life allergen sensitivity starts in the skin

Wed, 20 May 2026 13:47:45 +0000

Early life allergen sensitivity starts in the skin

Interaction between airway basal cells, mast cells and type 2 immunity contributes to epithelial barrier dysfunction in allergic rhinitis

Wed, 20 May 2026 13:46:47 +0000

Interaction between airway basal cells, mast cells and type 2 immunity contributes to epithelial barrier dysfunction in allergic rhinitis: www.mucosalimmunology.org/article/S193...

The most influential explanation of a recent surge in allergies is the hygiene hypothesis

Wed, 20 May 2026 13:44:44 +0000

The most influential explanation of a recent surge in allergies is the hygiene hypothesis

go.nature.com/40woBkB

Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection

Wed, 20 May 2026 13:43:41 +0000

Online now: Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection

Hyperactivation of sympathetic nerves fuels basophil infiltration in atopic dermatitis

Wed, 20 May 2026 13:42:41 +0000

Online now: Hyperactivation of sympathetic nerves fuels basophil infiltration in atopic dermatitis

Nature research paper: Environmentally driven immune imprinting protects

Wed, 20 May 2026 13:41:47 +0000

Nature research paper: Environmentally driven immune imprinting protects against allergy

go.nature.com/46lGExb

Neuro-epithelial circuits promote sensory convergence and intestinal immunity

Wed, 20 May 2026 13:40:03 +0000

Nature research paper: Neuro-epithelial circuits promote sensory convergence and intestinal immunity

go.nature.com/4qeRjlt

Mast cell-specific CysLT2 receptor signaling inhibits cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammation

Wed, 20 May 2026 13:39:10 +0000

Mast cell-specific CysLT2 receptor signaling inhibits cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammation

Mechanisms and clinical implications of gut-brain interactions

Wed, 20 May 2026 13:36:36 +0000

Review @jci.org
Mechanisms and clinical implications of gut-brain interactions
www.jci.org/articles/vie...

Germline-encoded recognition of peanut underlies development of convergent antibodies in humans

Wed, 20 May 2026 13:34:40 +0000

Humans may be genetically programmed to produce antibodies against peanut, suggests a #ScienceTranslationalMedicine study showing nonallergic people harbor convergent, germline-encoded antibodies against the allergen Ara h 2. https://scim.ag/3LqfEp9

In a #ScienceImmunology Review from earlier this year, researchers discuss how

Wed, 20 May 2026 13:33:36 +0000

In a #ScienceImmunology Review from earlier this year, researchers discuss how interactions between the nervous and immune systems could impact neurological disorders and allergy-related behaviors like food avoidance. https://scim.ag/3Y1hcsr

An anti-allergy vaccine protects mice from anaphylaxis for as long as one year,

Wed, 20 May 2026 13:32:02 +0000

This paper by Conde et al. demonstrates that a conjugate vaccine coupling a mutated human IgE fragment to a CRM carrier induces durable, neutralizing anti-IgE autoantibodies in humanized mice, providing long-term protection against systemic and cutaneous anaphylaxis without compromising anti-helminth immunity. #ScienceTranslationalMedicine. https://scim.ag/3XxHAdi

Central neural circuits underlying itch sensation — a Review by Yan-Gang

Wed, 20 May 2026 13:28:49 +0000

Central neural circuits underlying itch sensation — a Review by Yan-Gang Sun

#neuroscience #neuroskyence

www.nature.com/articles/s41...

Nature research paper: Maternal stress triggers early-life eczema through fetal

Wed, 20 May 2026 13:27:45 +0000

Nature research paper: Maternal stress triggers early-life eczema through fetal mast cell programming

go.nature.com/3UPz8Vm

The causes of early-life eczema have been unclear, but evidence indicates that

Wed, 20 May 2026 13:25:05 +0000

The causes of early-life eczema have been unclear, but evidence indicates that changes to fetal immune cells and sensory neurons during pregnancy play a key part

go.nature.com/45Y9aUQ